Science

Most conversations about longevity focus on tactics. This episode breaks down the biology underneath them. You’ll hear a systems level analysis of how insulin signaling, mTOR, mitochondrial function, inflammation, and nutrient sensing interact to determine biological age, disease risk, and long term human performance.

Judea Pearl is The Chancellor’s Professor of computer science and statistics and director of the Cognitive Systems Laboratory at UCLA. He was the recipient of the Turing Award in 2011. His latest book "Coexistence and Other Fighting Words – Selected Writings of Judea Pearl, 2002-2025" was released on December 10, 2025.

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Sam Harris speaks with Peter Zeihan about Trump's second term and its economic and geopolitical consequences. They discuss Zeihan's failed 2024 election prediction, the unprecedented unraveling of American power, Trump's tariff policies, the AI bubble, deglobalization and supply chain vulnerabilities, China's demograph

What if the most powerful predictor of your lifespan has nothing to do with your genetics, diet, workouts, or supplements? In this groundbreaking episode, neuroscientist Louisa Nicola sits down with bestselling author Shawn Stevenson to reveal the real missing piece in the longevity equation. Drawing from a massive 148

Pain isn’t just in your body, it’s in your brain. In this groundbreaking episode, Host Dave Asprey sits down with Dr. Daniel Amen to reveal how emotional and physical pain share the same neural circuits and how you can rewire them for relief, resilience, and longevity. You’ll learn practical tools to break the “doom lo