The Human Upgrade: Biohacking for Longevity & Performance

Updated: 10 Oct 2025 • 1399 episodes
daveasprey.com/category/podcasts

For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™. You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human. Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward. Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life. 

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What if you could improve your mitochondria, oxygen efficiency, and recovery in just 20 minutes a day—by breathing energized water? This episode explores one of the most surprising breakthroughs in biohacking and how it can help you live longer, think clearer, and perform better.  Watch this episode on YouTube for the

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AI is transforming medicine at a speed never seen before. In this episode, you’ll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtua

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Most people think about heart disease and metabolism when they talk about longevity, but too few talk about joint health. In this episode, you’ll discover how to biohack your joints to prevent pain, reverse damage, and move like you’re decades younger. Host Dave Asprey reveals how functional movement, core stability, a

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Remote work might feel like freedom, but your biology disagrees. In this video, I break down how your work-from-home setup is hijacking your hormones: crushing testosterone, spiking cortisol, and wrecking insulin sensitivity. I’ll show you exactly how posture, light, movement, and meal timing secretly control fat gain,

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03 Oct 2025 • EN

10-Minute Weekly Update

Upgrade your week in just 10 minutes with D(AI)ve Asprey’s essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom.  This episode covers:  • Apple Cider Vinegar Myth Busted  A weight-loss study just got retracted. ACV will not melt fat, but it may blunt glucose spikes or eas

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Gravity may be the most ignored signal in human biology, and it could be the missing key to unlocking fat loss, brain optimization, and true longevity. In this episode, you’ll learn how Earth’s pull shapes your metabolism, mood, and resilience, and discover practical hacks to fight “gravity intolerance” so you can perf

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