The Human Upgrade: Biohacking for Longevity & Performance

Updated: 02 Oct 2025 • 1394 episodes
daveasprey.com/category/podcasts

For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™. You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human. Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward. Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life. 

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Gravity may be the most ignored signal in human biology, and it could be the missing key to unlocking fat loss, brain optimization, and true longevity. In this episode, you’ll learn how Earth’s pull shapes your metabolism, mood, and resilience, and discover practical hacks to fight “gravity intolerance” so you can perf

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Most people chase fat loss, focus, and energy with caffeine or stimulants, but the real key to brain optimization and human performance is a pharmaceutical nootropic that activates your wakefulness circuits without jitters or a crash. In this episode, you’ll learn how Modafinil upgrades mitochondria, sharpens neuroplas

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Most people are struggling with fat loss, low energy, and hormone chaos—and they don’t even realize the real problem isn’t their diet or workout plan... it’s their liver. In this episode, I break down how your liver controls fat-burning, energy, and hormone regulation—and why things like poor bile flow and mineral defi

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26 Sep 2025 • EN

10-Minute Weekly Update

Upgrade your week in just 10 minutes with D(AI)ve Asprey’s essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. Each story includes trusted source links—so you can check the facts.  This episode covers:  - Rapamycin’s Reality Check:  A sweeping new review (September 24)

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Your mitochondria are the power plants of your cells, and when they break down, you lose energy, brain sharpness, and resilience against aging. In this episode, you’ll learn how to hack your mitochondria to supercharge human performance, prevent decline, and extend longevity with tools that are natural, effective, and

61 min
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Dave Asprey & Steven Pinker 23 Sep 2025 • EN

Steven Pinker: Outsmarting an Irrational World

Your brain isn’t as rational as you think, and that blind spot can wreck your decision-making, relationships, and even your health. In this episode, you’ll learn how to spot the hidden cognitive traps that even the smartest people fall for, and how to upgrade your thinking so you can perform better, live longer, and ma

63 min
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