Episode #279: Dr. Anurag Singh: Urolithin A, the Aging Immune System, Biological Age Reversal and more…

Are you protecting your immune system as you age?   In this Longevity podcast episode, I am joined by Dr. Anurag Singh to discuss recent research that suggests Urolithin A, a compound derived from pomegranates and other foods, may help rejuvenate the aging immune system.    We dive into how supplementing with Urolithin A for just 4 weeks led to significant improvements in immune cell function and a reduction in biological age by an average of 2 years in middle-aged adults. We also discuss insights on dosing, combining Urolithin A with other longevity strategies, and ongoing clinical trials that may reveal even more benefits.   Dr. Anurag Singh is the Chief Medical Officer of Timeline Nutrition, a biotech company focused on discovering and developing next generation natural compounds that target improvement in mitochondrial health. He began his career in 2003 as a Resident Medical Doctor at Northern Railway Divisional Hospital in Lucknow.    Go to TimelineNutrition.com/nat10 and/or use code Nat10 for a discount.   Thank you to our sponsors for making this episode possible:                                                                                                                                                           Element Health: Use code Longevity when shopping at https://elementhealthsupply.com/discount/Longevity  to save on your orders. Siphox: Visit http://SiPhoxhealth.com/nat  and save on your test.                                                                                                                                              Find more from Dr. Singh/Timeline:  Website: www.timelinenutrition.com  Instagram: @timeline_longevity   Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Join Nat’s Membership Community: https://www.natniddam.com/bsp-community  Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0  Instagram: https://www.instagram.com/nathalieniddam/  Website: www.NatNiddam.com    Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance    What We Discuss:   09:04 The Role of the Immune System in Aging 12:10 Understanding Immune Exhaustion and Inflammation 15:12 Mitochondrial Health and Immune Function 18:06 Urolithin A: Sources and Production 12:05 Research Studies on Urolithin A and Cancer 30:01 Clinical Trials and Future Directions 31:17 Understanding the Immune System 33:54 The Mitoimmune Randomized Control Trial 38:31 Dosing and Effects of Urolithin A 40:22 Biological Age Reversal and Longevity 44:33 Combining Strategies for Enhanced Benefits 49:21 Future Research Directions in Cancer and Neurodegeneration Studies Mentioned:  Mitochondrial Recycling Reverts Age-Associated Decline Urolithin-A Promotes CD8+ T Cell–mediated Cancer Immunosurveillance Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy Mitopure Impact on Immune Aging: RCT