Costly mistakes plague 49ers in first loss of 2025 NFL Season

An afternoon of errors resulted in the 49ers' first loss of the 2025 NFL season Sunday against the Jacksonville Jaguars. Despite a second-half comeback attempt, San Francisco couldn't overcome its four turnovers. Brock Purdy's looked shaky in his return from injury after missing the last two weeks with turf toe. Matt Maiocco and Jennifer Lee Chan discuss how a subpar performance from all three phases contributed to the 49ers' first defeat. Matt and Jennifer also address the curious postgame exchange between 49ers defensive coordinator Robert Saleh and Jaguars coach Liam Coen as the topic of sign-stealing could be a season-long storyline. -- (1:00) Thursday night matchup vs. Rams gives 49ers chance to turn the page quickly (4:00) Brock Purdy looked out-of-sync, but dropped passes didn't help (6:00) Is the lack of takeaways or red-zone woes the bigger concern? (15:00) Nick Bosa’s gravity on field and locker room noticeably missed in one game without him (21:00) The defensive line will need to step it up (31:00) Robert Saleh vs. Liam Coen sign-stealing saga Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.