Trazodone vs. Doxepin vs. Melatonin: Comparing Alternatives for Sleep

07 Nov 2025 • 11 min • EN
11 min
00:00
11:12
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In this episode, we explore a head-to-head comparison of trazodone, doxepin, and melatonin for treating insomnia when benzodiazepines are off the table. Which non-benzodiazepine sleep aid offers the best balance of effectiveness and tolerability in real-world psychiatric patients? Faculty: Paul Zarkowski, M.D. Host: Richard Seeber, M.D. Learn more about our membership here Earn 0.75 CMEs: Quick Take Vol. 74 Melatonin, Trazodone, or Doxepin for Sleep Disorders

From "Psychopharmacology and Psychiatry Updates"

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