Surviving Market Cycles & Startup Lessons for Founders

with @AriannaSimpson @jacqmelinek Crypto is known for its high and low market cycles: What must founders know — and what can they do — to survive the swings? In this episode, we unpack the lessons of past crypto cycles and how they shape the current wave of building — from stablecoins to AI x crypto. We also dive into the founder journey: from raising money and staying committed in 2025, to handling copycat competitors, cofounder disputes, growing too fast (or slowly), and more. You'll hear from a16z crypto General Partner Arianna Simpson, who has spent over a decade investing in crypto. She joins Jacquelyn Melinek, cofounder & CEO of Token Relations and host of the Talking Tokens podcast, where this conversation first aired, and which we’re excited to share with you here.  Timestamps 0:00 Introduction 1:19 Arianna Simpson's Crypto Origin Story 3:23 Market Cycles & Investing Priorities 5:52 Interrogating the Stablecoin Trend 13:25 Intersection of AI x Crypto 17:49 The Role of Blockchains for Authenticity and Verification 23:07 Future of AI Agents and Monetization Models 27:23 Traits of Successful Crypto Founders 30:05 Challenges and Changes in Fundraising 33:57 Current State of the Market 37:33 Advice for Founders:   • Pivoting when PMF is missing   • Raising capital after bootstrapping   • Competing with copycats   • Cofounder disputes and breakups   • Growing too fast & scaling pains 47:52 Conclusion *** 📩 Subscribe for more from a16z crypto: https://a16zcrypto.substack.com/subscribe/  🎙️ Like, subscribe, comment, share the show: https://a16zcrypto.com/posts/podcast/ *** As always, none of the content should be taken as investment, business, legal, or tax advice. Please see a16z.com/disclosures for more important information, including a link to a list of our investments.