Death Clock

This week's guest is William Porter, author of Alcohol Explained. He joins Brent to dismantle the myths that shape our cultural relationship with drinking. Drawing from his own history with addiction and the hyper-logical framework behind his books, Porter explains what alcohol actually does to the brain and body, to i

In this episode, Brent is joined by endocrinologist and longtime FDA leader Dr. G. Alexander Fleming to break down one of the most consequential diseases of modern life: type 2 diabetes. Dr. Fleming explains the real difference between type 1 and type 2, why insulin resistance is the root problem, and how biomarkers li

In this episode of Death Clock, Brent talks with Dr. Michael Fredericson, a Stanford physician and co-director of the Stanford Center on Longevity, about how to stay fit, strong, and injury-free as we age. Drawing on decades working with Olympic athletes and Stanford's track team, Dr. Fredericson breaks down the core p

This week, Brent speaks with Sir Adrian Bird, the pioneering geneticist whose discoveries on DNA methylation reshaped our understanding of how genes are regulated. Bird explains what DNA methylation actually is and why he's skeptical of popular claims that it determines "biological age" or can be easily hacked to rever

In this episode of Death Clock, Brent speaks with Dr. Nazish Sayed, a Stanford cardiologist and vascular biologist, to cut through the confusion about cholesterol, heart disease, and statins. Dr. Sayed breaks down what LDL, HDL, and ApoB really mean, why high cholesterol is more about your biology than your breakfast,

This week, Brent speaks with Dr. John Buse, a leading endocrinologist at the University of North Carolina and one of the world's foremost experts on diabetes and metabolic health. Dr. Buse unpacks the science behind GLP-1 agonists like Ozempic and Wegovy. He explains their powerful benefits for obesity, diabetes, and h